{"id":541,"date":"2023-03-13T11:50:31","date_gmt":"2023-03-13T04:50:31","guid":{"rendered":"https:\/\/conf.icgbio.ru\/bgrs98\/?page_id=541"},"modified":"2023-04-11T13:51:28","modified_gmt":"2023-04-11T06:51:28","slug":"033_specific-features-of-x-linked-promoter-sequences-in-drosophila","status":"publish","type":"page","link":"https:\/\/conf.icgbio.ru\/bgrs98\/abstracts\/abstract-list\/033_specific-features-of-x-linked-promoter-sequences-in-drosophila\/","title":{"rendered":"SPECIFIC FEATURES OF X-LINKED PROMOTER SEQUENCES IN DROSOPHILA"},"content":{"rendered":"<p><a href=\"https:\/\/conf.icgbio.ru\/bgrs98\/abstracts\/authors-index\/#arkhipova\">ARKHIPOVA IRINA R.<\/a><\/p>\n<p><a href=\"https:\/\/conf.icgbio.ru\/bgrs98\/abstracts\/keywords-index\/\">Keywords<\/a>: X chromosome, Drosophila promoters, dosage compensation<\/p>\n<p>&nbsp;<\/p>\n<p>The promoter regions of X-linked genes in Drosophila melanogaster differ from those of autosomal genes at the level of nucleotide sequence. While no conventional consensus can be deduced for X-specific elements, correlation analysis reveals significant over-representation for several classes of relatively simple sequence motifs in certain positions in the X-linked but not autosomal subsets of the aligned promoter database. These elements are broadly distributed over a distance of several hundred base pairs, extending from the 5&#8242; upstream flanking region far downstream into the transcribed region. In addition, TATA- containing promoters are strongly under-represented in the X chromosome subset. Taking into account the strand-specificity and positional distribution of X chromosome-specific sequences, it appears likely that the combined action of these multiple motifs could provide the cis-acting elements necessary and\/or sufficient for creating the unique chromatin structure of the male X chromosome in Drosophila and mediating the dosage compensation response. This is the first report of specific sequence motifs in a set of diverse genes connected only by their linkage relationship.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>ARKHIPOVA IRINA R. Keywords: X chromosome, Drosophila promoters, dosage compensation &nbsp; The promoter regions of X-linked genes in Drosophila melanogaster differ from those of autosomal genes at the level of nucleotide sequence. While no conventional consensus can be deduced for &hellip; <a href=\"https:\/\/conf.icgbio.ru\/bgrs98\/abstracts\/abstract-list\/033_specific-features-of-x-linked-promoter-sequences-in-drosophila\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":13,"featured_media":0,"parent":97,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/conf.icgbio.ru\/bgrs98\/wp-json\/wp\/v2\/pages\/541"}],"collection":[{"href":"https:\/\/conf.icgbio.ru\/bgrs98\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/conf.icgbio.ru\/bgrs98\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/conf.icgbio.ru\/bgrs98\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/conf.icgbio.ru\/bgrs98\/wp-json\/wp\/v2\/comments?post=541"}],"version-history":[{"count":3,"href":"https:\/\/conf.icgbio.ru\/bgrs98\/wp-json\/wp\/v2\/pages\/541\/revisions"}],"predecessor-version":[{"id":1367,"href":"https:\/\/conf.icgbio.ru\/bgrs98\/wp-json\/wp\/v2\/pages\/541\/revisions\/1367"}],"up":[{"embeddable":true,"href":"https:\/\/conf.icgbio.ru\/bgrs98\/wp-json\/wp\/v2\/pages\/97"}],"wp:attachment":[{"href":"https:\/\/conf.icgbio.ru\/bgrs98\/wp-json\/wp\/v2\/media?parent=541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}