Chiar:
Olga Lavrik, Institute of Chemical Biology and Fundamental Medicine
Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
Inna Lavrik, Otto von Guericke University, Magdeburg, Germany
Dmitry Zharkov, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
Sections (more):
The section on DNA Repair and Epigenetic Regulation of Genome Stability would be an extremely important.
The programmed cell death is essential property of all multicellular organisms.
P R O G R A M M E
SYMPOSIUM
«Systems biology of DNA repair processes and programmed cell death»
20-22 August 2018
Akademgorodok, Novosibirsk, Russia
Monday August 20, 2018
18h00 – 18h30: Registration
19h00: Get-together party
Tuesday August 21, 2018
Part 1. Systems biology of pharmacological targeting of apoptosis
Chairpersons: Inna Lavrik, Vladimir Ivanisenko
11:00-11:30 Inna Lavrik
Towards understanding of apoptosis regulation using computational biology
11:30-12:00 Nikita Ivanisenko
Novel approach for computational design of small molecule inhibitors of protein/protein interactions in CD95/FAS pathway
12:00-12:30 Vladimir A. Ivanisenko
Growth of interest to research in the field of medical genetics according to the analysis of scientific publications
12:30-12:50 Olga V. Saik
Analysis of Programmed Cell Death in Associative Gene Net-work of Glaucoma Reconstructed Using AND System
12:50-13:10 Nikolay Alemasov
Topological properties of graph of hydrogen bonds forming in SOD1 protein indicate critical regions in its structure
13:55-15:00 Lunch
Part 2. Cross talk between autophagy and apoptosis and their targeting
15:00-15:45 Boris Zhivotovsky
Cross-talk between apoptosis and autophagy: the role of suppressed translation
15:45-16:15 Lyudmila Gulyaeva
Role of miR-126a in regulation of expression of anti-apoptotic protein BCL2
16:15-16:45 Olga Koval
Novel therapeutic approaches based on lactaptin action
16:45-17:05 Anastasiya Tkachenko
Autophagy and lactaptin
17:05-17:30 A.A. Nemudraya
Tumor-Specific Peptide, Enhances Antitumor Activity of Lactaptin
17:30-18:00 Bernd Kaina
DNA Repair and death regulation in cells of the immune system
Wednesday August 22, 2018
Part 3. DNA Repair
Chairpersons: Olga Lavrik, Dmitry Zharkov
11:00-11:30 Gianluca Tell
Non canonical roles of BER enzymes in RNA processing: novel perspectives in cancer biology through the study of APE1 RNA- and protein-interactomes
11:30-11:50 Nikita A. Kuznetsov
Molecular model of DNA glycosylase stimulation by human apurinic/apyrimidinic endonuclease 1
11:50-12:20 Olga Lavrik
Poly(ADP-ribose) polymerase 1 in regulation of DNA repair and longevity
12:20-12:50 Alexander Ishchenko
Poly- and mono(ADP-ribosyl)ation of DNA strand breaks by PARP2 and PARP3 enzymes
12:50-13:10 Ekaterina Belousova
DNA Is a New Acceptor of PARP3 Protein
13:10-14:30 Lunch
14:30-14:50 Alexandra Zakharenko
TDP 1 Inhibitors as Potential Antitumor Drugs
14:50-15:20 Dmitry Zharkov
Targeted DNA Damage and Repair: The Cell’s Multitool for Genome Regulation
15:20-15:40 Inga Grin
Biological activity of the new photoactive ruthenium nitrosyl complexes: cytotoxicity and effects on DNA repair
15:40-16:00 Evgenia Dyatlova
Processivity of DNA repair enzymes
16:00-16:20 Anna Yudkina
Structural and biochemical insights on new atypical FPG/NEI DNA – Glycosylases
16:20-16:40 Coffee Break // Poster Session
16:40-17:00 Olga Kladova
Lesion recognition by bifunctional DNA-glycosylase Endo III and its catalytic mutants
17:00-17:20 Evgeniy S. Shilkin
Translesion DNA synthesis by DNA polymerase iota and it’s variants
17:20-17:40 Alena V. Makarova
The point mutations in the fingers domain increase the fidelity of DNA synthesis on undamaged DNA and abrogate DNA translesion synthesis in Y-family of DNA polymerases
17:40-18:00 Elizaveta Boldinova
In vitro lesion bypass by human PrimPol
Closing ceremony
