Председатели:
Лаврик Инна Николаевна, Университет им. Отто фон Герике, Магдебург, Германия
Лаврик Ольга Ивановна, ИХБФМ СО РАН, Новосибирск, Россия
Жарков Дмитрий Олегович, ИХБФМ СО РАН, Новосибирск, Россия
Секции:
1) Репарация ДНК и эпигенетическая регуляция.
2) Системная биология клеточной смерти.
Описание секций — ссылка.
Программа в формате .pdf.
P R O G R A M M E
SYMPOSIUM
«Systems biology of DNA repair processes and programmed cell death»
20-22 August 2018
Akademgorodok, Novosibirsk, Russia
Monday August 20, 2018
18h00 – 18h30: Registration
19h00: Get-together party
Tuesday August 21, 2018
Part 1. Systems biology of pharmacological targeting of apoptosis
Chairpersons: Inna Lavrik, Vladimir Ivanisenko
11:00-11:30 Inna Lavrik
Towards understanding of apoptosis regulation using computational biology
11:30-12:00 Nikita Ivanisenko
Novel approach for computational design of small molecule inhibitors of protein/protein interactions in CD95/FAS pathway
12:00-12:30 Vladimir A. Ivanisenko
Growth of interest to research in the field of medical genetics according to the analysis of scientific publications
12:30-12:50 Olga V. Saik
Analysis of Programmed Cell Death in Associative Gene Net-work of Glaucoma Reconstructed Using AND System
12:50-13:10 Nikolay Alemasov
Topological properties of graph of hydrogen bonds forming in SOD1 protein indicate critical regions in its structure
13:55-15:00 Lunch
Part 2. Cross talk between autophagy and apoptosis and their targeting
15:00-15:45 Boris Zhivotovsky
Cross-talk between apoptosis and autophagy: the role of suppressed translation
15:45-16:15 Lyudmila Gulyaeva
Role of miR-126a in regulation of expression of anti-apoptotic protein BCL2
16:15-16:45 Olga Koval
Novel therapeutic approaches based on lactaptin action
16:45-17:05 Anastasiya Tkachenko
Autophagy and lactaptin
17:05-17:30 A.A. Nemudraya
Tumor-Specific Peptide, Enhances Antitumor Activity of Lactaptin
17:30-18:00 Bernd Kaina
DNA Repair and death regulation in cells of the immune system
Wednesday August 22, 2018
Part 3. DNA Repair
Chairpersons: Olga Lavrik, Dmitry Zharkov
11:00-11:30 Gianluca Tell
Non canonical roles of BER enzymes in RNA processing: novel perspectives in cancer biology through the study of APE1 RNA- and protein-interactomes
11:30-11:50 Nikita A. Kuznetsov
Molecular model of DNA glycosylase stimulation by human apurinic/apyrimidinic endonuclease 1
11:50-12:20 Olga Lavrik
Poly(ADP-ribose) polymerase 1 in regulation of DNA repair and longevity
12:20-12:50 Alexander Ishchenko
Poly- and mono(ADP-ribosyl)ation of DNA strand breaks by PARP2 and PARP3 enzymes
12:50-13:10 Ekaterina Belousova
DNA Is a New Acceptor of PARP3 Protein
13:10-14:30 Lunch
14:30-14:50 Alexandra Zakharenko
TDP 1 Inhibitors as Potential Antitumor Drugs
14:50-15:20 Dmitry Zharkov
Targeted DNA Damage and Repair: The Cell’s Multitool for Genome Regulation
15:20-15:40 Inga Grin
Biological activity of the new photoactive ruthenium nitrosyl complexes: cytotoxicity and effects on DNA repair
15:40-16:00 Evgenia Dyatlova
Processivity of DNA repair enzymes
16:00-16:20 Anna Yudkina
Structural and biochemical insights on new atypical FPG/NEI DNA – Glycosylases
16:20-16:40 Coffee Break // Poster Session
16:40-17:00 Olga Kladova
Lesion recognition by bifunctional DNA-glycosylase Endo III and its catalytic mutants
17:00-17:20 Evgeniy S. Shilkin
Translesion DNA synthesis by DNA polymerase iota and it’s variants
17:20-17:40 Alena V. Makarova
The point mutations in the fingers domain increase the fidelity of DNA synthesis on undamaged DNA and abrogate DNA translesion synthesis in Y-family of DNA polymerases
17:40-18:00 Elizaveta Boldinova
In vitro lesion bypass by human PrimPol
Closing ceremony