Председатели:
Лаврик Инна Николаевна, Университет им. Отто фон Герике, Магдебург, Германия
Лаврик Ольга Ивановна, ИХБФМ СО РАН, Новосибирск, Россия
Жарков Дмитрий Олегович, ИХБФМ СО РАН, Новосибирск, Россия

Секции: 
1) Репарация ДНК и эпигенетическая регуляция.
2) Системная биология клеточной смерти.

Описание секций — ссылка.
Программа в формате .pdf.

 

P R O G R A M M E

SYMPOSIUM
«Systems biology of DNA repair processes and programmed cell death»
20-22 August  2018
Akademgorodok, Novosibirsk, Russia

Monday August 20, 2018
18h00 – 18h30: Registration
19h00: Get-together party

Tuesday August 21, 2018
Part 1. Systems biology of pharmacological targeting of apoptosis
Chairpersons: Inna Lavrik, Vladimir Ivanisenko

11:00-11:30    Inna Lavrik
Towards understanding of apoptosis regulation using computational biology

11:30-12:00    Nikita  Ivanisenko
Novel approach for computational design of small molecule inhibitors of protein/protein interactions in CD95/FAS pathway

12:00-12:30   Vladimir A. Ivanisenko
Growth of interest to research in the field of medical genetics according to the analysis of scientific publications

12:30-12:50    Olga V. Saik
Analysis of Programmed Cell Death in Associative Gene Net-work of Glaucoma Reconstructed Using AND System

12:50-13:10    Nikolay Alemasov
Topological properties of graph of hydrogen bonds forming in SOD1 protein indicate critical regions in its structure

13:55-15:00 Lunch

Part 2. Cross talk between autophagy and apoptosis and their targeting   

15:00-15:45    Boris Zhivotovsky
Cross-talk between apoptosis and autophagy: the role of suppressed translation

15:45-16:15    Lyudmila Gulyaeva
Role of miR-126a in regulation of expression of anti-apoptotic protein BCL2

16:15-16:45    Olga Koval
Novel therapeutic approaches based on lactaptin action

16:45-17:05    Anastasiya Tkachenko
Autophagy and lactaptin

17:05-17:30    A.A. Nemudraya
Tumor-Specific Peptide, Enhances Antitumor Activity of Lactaptin

17:30-18:00    Bernd Kaina
DNA Repair and death regulation in cells of the immune system

 

Wednesday August 22, 2018

Part 3. DNA Repair
Chairpersons: Olga Lavrik, Dmitry Zharkov

11:00-11:30    Gianluca Tell
Non canonical roles of BER enzymes in RNA processing: novel perspectives in cancer biology through the study of APE1 RNA- and protein-interactomes

11:30-11:50    Nikita A. Kuznetsov
Molecular model of DNA glycosylase stimulation by human apurinic/apyrimidinic endonuclease 1

11:50-12:20    Olga Lavrik
Poly(ADP-ribose) polymerase 1 in regulation of DNA repair and longevity

12:20-12:50    Alexander Ishchenko
Poly- and mono(ADP-ribosyl)ation of DNA strand breaks by PARP2 and PARP3 enzymes

 12:50-13:10    Ekaterina Belousova
DNA Is a New Acceptor of PARP3 Protein

13:10-14:30 Lunch

 14:30-14:50    Alexandra Zakharenko
TDP 1 Inhibitors as Potential Antitumor Drugs

14:50-15:20    Dmitry Zharkov
Targeted DNA Damage and Repair: The Cell’s Multitool for Genome Regulation

15:20-15:40    Inga Grin
Biological activity of the new photoactive ruthenium nitrosyl complexes: cytotoxicity and effects on  DNA repair

15:40-16:00   Evgenia Dyatlova
Processivity of DNA repair enzymes

16:00-16:20  Anna Yudkina
Structural  and biochemical  insights on new atypical FPG/NEI  DNA – Glycosylases

16:20-16:40        Coffee Break // Poster Session

16:40-17:00   Olga Kladova
Lesion recognition by bifunctional DNA-glycosylase Endo III and its catalytic mutants 

17:00-17:20   Evgeniy S. Shilkin
Translesion DNA synthesis by DNA polymerase iota and it’s variants

17:20-17:40   Alena V. Makarova
The point mutations in the fingers domain increase the fidelity of DNA synthesis on undamaged DNA and abrogate DNA translesion synthesis in Y-family of DNA polymerases

17:40-18:00   Elizaveta Boldinova
In vitro lesion bypass by human PrimPol

Closing ceremony