Seminar «Systems biology of programmed cell death» is dedicated to issues, investigated under scientific work supported by Russian Science Foundation grant “Programmed cell death induced via death receptors: Delineating molecular mechanisms of apoptosis initiation via molecular modeling” № 14-44-00011.
The project is aimed to the development of small molecules targeting the key components of the death receptor-mediated apoptotic pathway and use these compounds in the following studies of the mechanisms of apoptosis regulation. This will be achieved by computational molecular modelling and systematic structure-based molecular docking screens on the core proteins of DISC combined with experimental validation on the human cancer cell lines and mouse models. These small compounds would target the key Inhibitors of the death receptor pathway, which would allow to specifically activate apoptosis via death receptors. Furthermore, these studies would pave the way to the pionering discoveries in the field of cell death and would allow to discover new therapies for the treatment of diseases associated with defects in the death receptor system.
The seminar will take place on 24th of August at 9.00 in the conference hall (main building, 3rd floor), ICG SBRAS.
List of reports:
- «SYSTEMS BIOLOGY OF PROGRAMMED CELL DEATH» Prof. Lavrik I.N., Otto von Guericke University Magdeburg Department of Translational Inflammation Research (Magdeburg), Germany
- “VIRTUAL SCREENING OF CHEMICAL COMPOUNDS REGULATING CELL DEATH”, Ivanisenko N.V., Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia
- “AUTOMATED KNOWLEDGE EXCTRACTION FROM LITERATURE IN THE FIELD OF CELL DEATH”, Dr. Ivanisenko V.A., Saik O.V., Demenkov P.S., Ivanisenko T.V., Tiys E.S., Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia
- “MOSAIC GENE NETWORK MODELLING IDENTIFIED NEW REGULATORY MECHANISMS IN HCV INFECTION”, Petrovaskaya O.V., Petrovaskiy E.D., Ivanisenko V.A., Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia
- “IDENTIFICATION OF PATHWAYS ASSOCIATED WITH CELL DEATH IN THE CORTEX OF OXYS RATS AS THE SIGNS OF ALZHEIMER’S DISEASE DEVELOP” G.K. Suvorov, Federal research center Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia
- “TARGETING CD95/FAS SIGNALING WITH PEPTIDES DERIVED FROM V-FLIP/NEMO CRYSTAL STRUCTURE”, Buchbinder J.H., Lavrik I.N., Translational Inflammation Research, Otto-von-Guericke University Magdeburg, Germany