Analysis of genome data needs integration of databases on next generation sequencing, gene expression and gene functional annotation. We consider examples of whole-genome sequencing data processing using tools and databases from UCSC Genome Browser, ENCODE project, NCBI and Ensembl. We will discuss here problems of NGS data analysis including ChIP-seq, ChIP-exo, ChIA-PET methods.
Also, a computer assisted study of genomes of primates, ancient and modern humans can reveal insight to evolution processes. Computer models of molecular evolution and phylogenetically connected clusters of orthologous proteins, programming languages in biophysics and high performance computing simulation of evolutionary processes will be discussed on the section.